![]() This might have been due to irreversible or vitamin-independent neurocognitive decline or to an insufficient dose or duration of vitamins. It is a filter from which we then select the important. Oral B vitamin treatment normalized plasma tHcy and serum MMA concentrations but did not affect movement or cognitive performance. Short term memory is biologically designed to be a limited-capacity processor (only 57 items). Neither vitamin therapy nor changes in plasma tHcy, serum MMA, serum vitamin B-12, plasma folate, or whole-blood folate correlated with changes in movement or cognitive performance.Ĭonclusions: High plasma tHcy and serum MMA were prevalent and correlated inversely with movement and cognitive performance. No improvements were found in the movement or cognitive tests compared with placebo. Vitamin therapy significantly decreased plasma tHcy (32%) and serum MMA (14%). Movement time, digit symbol, and block design (adjusted for age, sex, smoking, and creatinine) correlated independently with plasma tHcy ( P < 0.01, < 0.05, and < 0.01, respectively) the simultaneity index and block design correlated with serum MMA ( P < 0.05 for both). Results: A high plasma total homocysteine (tHcy) concentration (≥16 μmol/L) was found in 64% of men and in 45% of women, and a high serum methylmalonic acid (MMA) concentration (≥0.34 μmol/L) was found in 11% of both sexes. Movement and cognitive performance tests were performed before and after treatment. Objective: The objective was to explore any association between vitamin status and vitamin treatment and movement and cognitive performance in elderly subjects.ĭesign: Community-dwelling subjects ( n = 209) with a median age of 76 y were randomly assigned to daily oral treatment with 0.5 mg cyanocobalamin, 0.8 mg folic acid, and 3 mg vitamin B-6 or placebo (double blind) for 4 mo. The clinical significance remains unresolved. Background: Deficiencies of vitamin B-12, folic acid, and vitamin B-6-as defined by laboratory measures-occur in 10–20% of elderly subjects. The Spain Schengen Visa is a short term visa for Spain that gives the right to its visa holder to enter Spain, and remain there for a maximum of 90 days within a 180 day period.
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